New deadly disease dubbed VEXAS gives men fevers, blood clots, and inflammation

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The VEXAS syndrome, 'The VEXAS syndrome': Scientists discover a rare and deadly inflammatory disorder in men, Scientists discover a rare and deadly inflammatory disorder in men
‘The VEXAS syndrome’: Scientists discover a rare and deadly inflammatory disorder in men. Picture: genome.gov

There are likely hundreds of men in the United States, if not more, who suffer from a just-discovered genetic disease that causes symptoms including blood clots in veins, recurrent fevers, lung system abnormalities, and — in 40% of patients — death. 

Researchers from the National Institutes of Health discovered the disease, named VEXAS, by working backwards: Rather than grouping people with similar symptoms and searching for biological explanations, they searched the genetic makeup of 2,500 people for variations that could be linked to the wide-ranging symptoms of their undiagnosed inflammatory conditions. 

We had many patients with undiagnosed inflammatory conditions who were coming to the NIH Clinical Center, and we were just unable to diagnose them,” said Dr. David B. Beck, clinical fellow at NHGRI and lead author of the paper.

That’s when we had the idea of doing it the opposite way. Instead of starting with symptoms, start with a list of genes. Then, study the genomes of undiagnosed individuals and see where it takes us.

Using that method, the scientists eventually identified three middle-aged men who all had the same mutations in a gene called UBA1. They later discovered 22 other men with the same mutations and similar symptoms, like blood clots and fevers. 

The research team named the disease VEXAS after its key characteristics: vacuoles (unusual cavity-like structures in certain cells), E1 enzyme (which is related to UBA1), X-linked (per the chromosome it’s connected to), autoinflammatory (meaning the immune system accidentally attacks the body) and somatic (since the condition seems ot pop up sometime during the patient’s life, rather than at birth).

The researchers suspect VEXAS has only been found in men because it’s linked to the X chromosome, of which men only have one. Women’s additional X chromosome, they hypothesize, could be protective in this case. 

Since the paper was published, 25 more patients with the syndrome have been found, but the study authors expect the true prevalence to be much higher – there are nearly 125 million people in the US with some form of a chronic inflammatory disease. 

Well hopefully this research will open up a whole world of potential therapeutics down the line. More medical news on Yahoo, Strange Sounds and Steve Quayle.

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10 COMMENTS

  1. VEXAS:
    Not sure what to make out of this one?

    Don’t get sciatica. That condition is very painful. Nerve pain is pretty bad, as medicines don’t work. I don’t use alcohol or pain meds. Don’t like these.

    I use extreme pressure on nerve for 30 seconds. Then release pressure. Seems to block the pain out. I don’t know why it works.

  2. BS! If this man-made targeted disease was because of men’s one less chromosome, it would not be a “new” disease!!

  3. Internet shut down is coming for the worst case senario after elections. Hackers are attacking USA every day , hospitals,
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  4. Jesus Christ is Love. Jesus christo estas amore, todo estas la humanidad de la mondo. La Paz.
    18 ATM Machines ‘Blown Apart’ in Two Nights of Philadelphia Riots
    Police reports indicate that 18 ATM machines were “blown apart” during two nights of rioting in Philadelphia. The incidents took place as rioters and looters ransacked the city following the shooting of an armed black man.

    Fox29 Philadelphia reporter Steve Keeley tweeted police reports showing multiple ATM machines being “blown apart” by looters attempting to steal cash from the machines. The reports indicate the destruction of 18 ATM machines throughout the Philadelphia area during two nights of rioting and looting.

  5. Michel L
    Se qui serait bon de regardé pour les personne atteint de ce mal des gênes. On t’il été vacciné par un composer ADN. Ils devrais vérifier quelle vaccin il ont reçue et faire des recherche. Que Dieu vous bénisse en Jésus Christ.

  6. Please strange sounds put full moon of OCT 31 and COVID and Generally new lock down so we can put it in right places if you have time.
    Iraqi Militia Leader In Tehran Threatens ‘Large And Bloody’ Attacks Against US
    Thursday, 29 Oct 2020 13:59

    The leader of the Iraqi Harakat Hezbollah al-Nujaba, a paramilitary force close to Iran, has said in Tehran that Shiite militias will launch “large and bloody” attacks against the United States interests if Washington does not withdraw its troops from Iraq, Tasnim news agency reported October 29.

    Sheikh Akaram Al-Kaabi in a press conference in Tehran said attacks against US interests so far have been simple “fireworks” but more serious “killer” attacks will follow if US troops stay.

    Al-Nujaba is one of the proxy forces Iran finances and arms in Iraq and it is part of the Iraqi Shiite Popular Mobilization Forces (PMF) that operates both in Iraq and in Syria.

    Forces comprising PMF have been lobbing rockets and mortar shells against the US embassy in Baghdad and military bases hosting US troops for the past few years. Such operations and a physical crowd attack on the US embassy in December 2019 preceded the targeted killing of Qasem Soleimani, the Iranian general coordinating the Islamic Republic’s military and political network in the Middle east.

    Al-Kaabi is quoted as saying that revenge for Soleimani’s killing is not limited to one Iraqi “resistance” group and all will join forces to expel the US military from the country. He added that once the Iraqi government sets a date for the exit of US forces and Washington does not comply, it will present a good reason for “resistance groups” to renew their attacks.

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    Mohsen BC

  7. Leeds and West Yorkshire go into Tier 3: Ten million people under the strictest Covid restrictions as another 16 authorities join Tier 2 and UK creeps toward full lockdown – with 23,065 cases and 280 deaths today, 40 per cent up in a week

    Muslims ‘have the right to kill millions of French people’, Malaysia’s former PM says after church terror attack in Nice

    Malaysia’s ex-PM Mahathir Mohamad launched an extraordinary outburst after the attack in Nice today
    The 95-year-old politician said in a now-removed tweet Muslims have a right ‘to kill millions of French people’
    He said freedom of speech does not include ‘insulting other people’ amid row over cartoons of the Prophet
    Malaysia’s ex-PM said: ‘The French should teach their people to respect other people’s feelings.

    ‘Since you have blamed all Muslims and the Muslims’ religion for what was done by one angry person, the Muslims have a right to punish the French.

    ‘The boycott cannot compensate the wrongs committed by the French all these years.’

    It also comes less than two weeks after a schoolteacher, Samuel Paty, was beheaded north of Paris for showing cartoons of the Prophet to his class in a lesson on free speech.

    Today, Vincent Loques, 45, a sacristan of the Notre Dame basilica in the city of Nice, was brutally killed as he prepared for the first Mass of the day after 21-year-old Tunisian migrant Brahim Aoussaoui attacked the church.

    Aoussaoui is thought to have beheaded an elderly female parishioner who had come to to pray as the church opened before attacking Loques, then fatally stabbing a second woman who ran across the street before dying of her injuries. Armed police arrived 10 minutes later and shot Aoussaoui, before arresting him.

    Elsewhere a security guard was stabbed and wounded outside the French consulate in Jeddah, Saudi Arabia, while two other men were arrested – one while carrying a knife near a church in Sartrouville after his father reported he was about to carry out a Nice-style attack, and another who tried to board a train in Lyon carrying a long blade.

    It was thought that police had foiled another Islamist attack in the town of Avignon when an armed man was shot dead by officers after refusing to drop his weapon.

    However, it later transpired the man was part of the far-Right, anti-Islam Identarian Movement, and had made a Nazi Salute. French media initially reported the man shouted ‘Allahu Akbar’, which turned out to be incorrect.

    Mr Macron travelled to Nice following the attack and gave a speech shortly after 3pm, as church bells sounded across France to honour the dead. The President said it was ‘clear that France that is under attack… because of our values of freedom and our desire not to give in to terror’. Nice attack as well. As i told you gates of hell is fully opened up for all humanity. National Emergency will be soon called for entire USA and Canada and troops will rool in with tanks and F35 ? Election riots , followed by the lootings and police can not handle any thing and troops will rool in hours after riots? Quake of 7 plus will hit in ring of fire and entire west coast of USA?Will election be null and void? Will election civil war already started, tonight is 4 th night looting in PHILLY ,PDX,SEATTLE,and LOUIVILLE,…. World is also mess indeed. Australia is going to be re lock down after a student diagnosed COVID 20. Is election entratinment for all of us while lock down of USA continues?

  8. We have been major breached by terrorist regime of Iran. We have no fears , we can not be shut down by bunch of donkeys in Iran. As we spoken we had to brinng our system up took a lot of time but we will speak of truth until regime of Iran will be cut off.
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    I do it for humanity , if i get 20 Millions , i will have to give strange sounds and Jason A .So let me work on my project.
    I will take care of my all friends indeed.
    Mohsen BC

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    Air Force scrambles F-16 to fire flares and warn off an unauthorized aircraft which had entered air space over Donald Trump’s Arizona rally

    Donald Trump was in Bullhead City in Arizona on Wednesday
    As he was speaking a F-16 was scrambled to investigate an unexplained plane
    The fighter jet released emergency flares to force the plane to make contact
    The plane was then safely escorted away from the area by the F-16
    Trump was delighted, saying: ‘They gave the president a little display!’

    France announces second national lockdown: Macron says coronavirus second wave will be worse than first and doing nothing will kill 400,000 people – but schools will stay open

    French President Macron has announced a new nationwide lockdown today, to come into force on Friday
    Macron told the country: ‘France could never standby and see hundreds of thousands of its citizens die.’
    Projections show 9,000 covid-19 patients will be in ICU by mid November, the country has 6,000 ICU beds
    Schools are to remain open as Macron said their previous closure had been ‘damaging’, universities to close

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