Question: Is Parkinson disease risk increased in military service members who were stationed at Marine Corps Base Camp Lejeune, North Carolina, during 1975-1985 when the water supply was contaminated with trichloroethylene and other volatile organic compounds?
Findings: This cohort study of 340 489 service members found that the risk of Parkinson disease was 70% higher in Camp Lejeune veterans compared with veterans stationed at a Marine Corps base where water was not contaminated. In veterans without Parkinson disease, risk was also significantly higher for several prodromal features of Parkinson disease.
Meaning: The study’s findings suggest that exposure to trichloroethylene in water may increase the risk of Parkinson disease; millions worldwide have been and continue to be exposed to this ubiquitous environmental contaminant.
[More: JAMA Neurology]